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The development of infectious inflammation of the aorta is promoted by damage to its endothelium in the area of the aneurysm or (in its absence) atherosclerosis. The most common pathogens that cause infectious aortitis are Staphylococcus aureus and Salmonella. The latter accounts for about 50% of Cefuroxime of this disease (J. Ewart et al., 1983), which is explained by its ability to penetrate intact endothelium. Infectious inflammation begins in the vasa vasorum and spreads to all membranes of the aorta.
The disease is especially common in Asia, but also occurs in all other countries of the world. Its etiology is unknown, the pathogenesis is presumably autoimmune. An important role is played by hereditary predisposition. The most characteristic is the lesion of the aorta, more often the arch and branches extending from it in the region of their mouths (the so-called type I nonspecific aortoarteritis).